Activation of Liver X Receptor Alleviates Ocular Inflammation in Experimental Autoimmune Uveitis
Investigative Ophthalmology & Visual Science2014Vol. 55(4), pp. 2795–2795
Citations Over TimeTop 10% of 2014 papers
Abstract
TO90 activates LXRα and potently attenuates ocular inflammation in EAU. Alleviation of ocular inflammation could partially result from inhibition of the NF-κB signaling pathway. TO90 reduces IFN-γ and IL-17 expression in both prevention and treatment scenarios. Our data suggest that the LXR agonist may become a novel class of therapeutic agent for autoimmune uveitis.
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