Spontaneous CNV in a Novel Mutant Mouse Is Associated With Early VEGF-A–Driven Angiogenesis and Late-Stage Focal Edema, Neural Cell Loss, and Dysfunction
Investigative Ophthalmology & Visual Science2014Vol. 55(6), pp. 3709–3709
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Norihiro Nagai, Pete Lundh von Leithner, Kanako Izumi‐Nagai, Brett Hosking, Bo Chang, R.E. Hurd, Peter Adamson, Anthony P. Adamis, Richard Foxton, Yin‐Shan Ng, David T. Shima
Abstract
The sCNV mouse is a new model for the study of both early and late events associated with choroidal neovascularization. Pharmacological reduction in sCNV with VEGF-A antagonists and an anti-inflammatory strategy suggests the model may be useful for investigating novel targets for treating human ocular neovascular disease.
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