Genotype-Dependent Variability in Residual Cone Structure in Achromatopsia: Toward Developing Metrics for Assessing Cone Health
Investigative Ophthalmology & Visual Science2014Vol. 55(11), pp. 7303–7303
Citations Over TimeTop 10% of 2014 papers
Adam M. Dubis, Robert F. Cooper, Jonathan Aboshiha, Christopher S. Langlo, Venki Sundaram, Benjamin Liu, Frederick T. Collison, Gerald A. Fishman, Anthony T. Moore, Andrew R. Webster, Alfredo Dubra, Joseph Carroll, Michel Michaelides
Abstract
We present cone reflectivity as a metric that can be used to characterize cone structure in ACHM. This method may be applicable to subjects with other cone disorders. In ACHM, we hypothesize that cone numerosity (and/or density) combined with cone reflectivity could be used to gauge the therapeutic potential. As gene replacement would not be expected to add cones, reflectivity could be a more powerful AO-metric for monitoring the cellular response to treatment and could provide a more immediate indicator of efficacy than behavioral measures, which may take longer to change.
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