Evidence for the involvement of MMP14 in MMP2 processing and recruitment in exosomes of corneal fibroblasts
Investigative Ophthalmology & Visual Science2014Vol. 56(9), pp. 5323–9
Citations Over TimeTop 23% of 2014 papers
Abstract
Our results indicate that exosomes secreted by corneal fibroblasts can transport proteins, including MMP14, to vascular endothelial cells. In addition, recruitment of MMP2 into corneal fibroblast exosomes is an active process that depends, at least in part, on the presence of MMP14. The role of exosomal MMP14 transport in corneal angiogenesis has important implications for therapeutic applications targeting angiogenic processes in the cornea.
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