Oxytocin Expression and Function in the Posterior Retina: A Novel Signaling Pathway
Investigative Ophthalmology & Visual Science2015Vol. 56(2), pp. 751–760
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Patrick Halbach, D.-A. M. Pillers, N York, Matti P. Asuma, Michelle Chiu, Wenxiang Luo, Sara Tokarz, Ian M. Bird, Bikash R. Pattnaik
Abstract
Oxytocin and OXTR are present in the posterior retina, and OXT induces an increase in hfRPE [Ca(2+)]i. These results suggest that the OXT-OXTR signaling pathway is active in the retina. We propose that OXT activation of the OXTR occurs in the posterior retina and that this may serve as a paracrine signaling pathway that contributes to communication between the cone photoreceptor and the RPE.
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