Prevalence of MitochondrialND4Mutations in 1281 Han Chinese Subjects With Leber's Hereditary Optic Neuropathy
Investigative Ophthalmology & Visual Science2015Vol. 56(8), pp. 4778–4778
Citations Over TimeTop 10% of 2015 papers
Pingping Jiang, Min Liang, Juanjuan Zhang, Yinglong Gao, Zheyun He, Han Yu, Fuxin Zhao, Yanchun Ji, Xiaoling Liu, Minglian Zhang, Qun Fu, Yi Tong, Yanhong Sun, Xiangtian Zhou, Taosheng Huang, Jia Qu, Min‐Xin Guan
Abstract
These results suggested that the ND4 gene is the hot spot for mutations associated with LHON. Thus, these findings may provide valuable information for the further understanding of pathogenic mechanism of LHON.
Related Papers
- → Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background(2007)356 cited
- → T14484C and T14502C in the mitochondrial ND6 gene are associated with Leber’s hereditary optic neuropathy in a Chinese family(2008)38 cited
- → Low penetrance of the 14484 LHON mutation when it arises in a non‐haplogroup J mtDNA background(2003)63 cited
- → Very high penetrance and occurrence of Leber’s hereditary optic neuropathy in a large Han Chinese pedigree carrying the ND4 G11778A mutation(2010)39 cited
- → Author Response: Penetrance of the LHON Mutation m.11778G>A May Depend on Factors Other Than Haplotype or Heteroplasmy Rate(2018)2 cited