(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism
Investigative Ophthalmology & Visual Science2016Vol. 57(2), pp. 453–453
Citations Over TimeTop 10% of 2016 papers
Jing Zhao, Barbara A. Mysona, Azam Qureshi, Lily Kim, Taylor Fields, Graydon B. Gonsalvez, Sylvia B. Smith, Kathryn Bollinger
Abstract
Targeting σR1 activation prevented RGC death while enhancing activation of the mitogen-activated protein kinase (MAPK), ERK1/2. Sigma-1 receptor is a promising therapeutic target for retinal neurodegenerative diseases.
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