Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD)
Investigative Ophthalmology & Visual Science2016Vol. 57(6), pp. 2463–2463
Citations Over TimeTop 16% of 2016 papers
Monika Fleckenstein, Felix Graßmann, Moritz Lindner, Maximilian Pfau, J Czauderna, Tobias Strunz, Claudia von Strachwitz, Steffen Schmitz-Valckenberg, Frank G. Holz, Bernhard H. F. Weber
Abstract
The dt-GA phenotype shows a remarkably different genetic risk profile from other GA phenotypes secondary to AMD. Disease-associated C1QTNF5 mutations were not identified. Together, these results suggest that the dt-GA phenotype is associated with a genetic background substantially different from other GA phenotypes and underlines the necessity to refine the clinical phenotyping, specifically when aiming for individualized therapies in AMD.
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