Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
Investigative Ophthalmology & Visual Science2017Vol. 58(2), pp. 708–708
Citations Over TimeTop 1% of 2017 papers
Matthew Pilgrim, Imre Lengyel, Antonio Lanzirotti, M. Newville, Sarah Fearn, Eszter Emri, Jonathan C. Knowles, Jeffrey D. Messinger, Russell W. Read, Clyde Guidry, Christine A. Curcio
Abstract
The data suggest that sub-RPE deposit formation is initiated, and probably regulated, by the RPE, as well as the loss of permeability of the Bruch's membrane and choriocapillaris complex associated with age and early AMD. This cell culture model of early AMD lesions provides a novel system for testing new therapeutic interventions against sub-RPE deposit formation, an event occurring well in advance of the onset of vision loss.
Related Papers
- → Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells(2008)48 cited
- → Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer(2018)23 cited
- → Characteristics of drusen and Bruch's membrane in post-mortem eyes with age-related macular degeneration(1998)37 cited
- [Drusen in Bruch's membrane. Their significance for the pathogenesis and therapy of age-associated macular degeneration].(1992)
- → Retinal Pigment Epithelium and Bruch Membrane(2021)