Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro
Investigative Ophthalmology & Visual Science2017Vol. 58(10), pp. 4318–4318
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Abstract
Sema3A is expressed in the retina after detachment, binds to rod photoreceptors, affects cell orientation, and reduces photoreceptor process initiation in vitro. Our results suggest that Sema3A contributes to axonal retraction in retinal injury, whereas rod neuritic sprouting and regenerative synaptogenesis may require a reduction in semaphorin signaling.
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