Evidence for Cerebrospinal Fluid Entry Into the Optic Nerve via a Glymphatic Pathway
Investigative Ophthalmology & Visual Science2017Vol. 58(11), pp. 4784–4784
Citations Over TimeTop 10% of 2017 papers
Abstract
To our knowledge, this is the first evidence of a glymphatic pathway in the optic nerve. CSF enters the optic nerve via spaces surrounding blood vessels, bordered by astrocytic endfeet. CSF entry into paravascular spaces of the optic nerve is size-dependent, and this pathway may be highly relevant to optic nerve diseases, including glaucoma.
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