Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma
Investigative Ophthalmology & Visual Science2018Vol. 59(1), pp. 446–446
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Anthony B. Daniels, Michael T. Froehler, Janene Pierce, Amy H. Nunnally, M. Wade Calcutt, Thomas M. Bridges, David C. LaNeve, Phillip E. Williams, Kelli L. Boyd, Michelle L. Reyzer, Craig W. Lindsley, Debra L. Friedman, Ann Richmond
Abstract
This first small-animal model of IAC has excellent vitreous and retinal tissue drug penetration, achieving levels sufficient to kill human retinoblastoma cells, facilitating future IAC drug discovery.
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