A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis
Investigative Ophthalmology & Visual Science2018Vol. 59(2), pp. 878–878
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Fleurieke H. Verhagen, Cornelis P. J. Bekker, Marzia Rossato, Sanne Hiddingh, Lieuwe de Vries, Abhinandan Devaprasad, Aridaman Pandit, Jeannette Ossewaarde‐van Norel, Ninette ten Dam, Maartje C. A. Moret-Pot, Saskia M. Imhof, Joke H. de Boer, Timothy R. D. J. Radstake, Jonas J. W. Kuiper
Abstract
PURPOSE. The cause of noninfectious uveitis (NIU) is poorly understood but is considered to be mediated by a complex interplay between genetic, environmental, and-relatively unexplored-epigenetic factors. MicroRNAs (miRNAs) are noncoding small RNAs that are important epigenetic regulators implicated in pathologic signaling. Therefore, we mapped the circulating miRNA-ome of NIU patients and studied miRNA perturbations within the broader context of the immune system.
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