Failure of Autophagy–Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed inCln6nclfMice
Investigative Ophthalmology & Visual Science2018Vol. 59(12), pp. 5082–5082
Citations Over TimeTop 19% of 2018 papers
Philipp von Eisenhart-Rothe, Alexandra Grubman, Ursula Greferath, Linda J. Fothergill, Andrew I. Jobling, Joanna A. Phipps, Anthony R. White, Erica L. Fletcher, Kirstan A. Vessey
Abstract
These results suggest that rod photoreceptors have an increased sensitivity to disturbances in the autophagy-lysosomal pathway and the subsequent failure of mitochondrial turnover, relative to other retinal cells. It is likely that primary failure of the rod photoreceptors rather than the RPE or other retinal neurons underlies the early visual dysfunction that occurs in the Cln6nclf mouse model.
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