Adaptive Optics Retinal Imaging inCNGA3-Associated Achromatopsia: Retinal Characterization, Interocular Symmetry, and Intrafamilial Variability
Investigative Ophthalmology & Visual Science2019Vol. 60(1), pp. 383–383
Citations Over TimeTop 10% of 2019 papers
Michalis Georgiou, Katie M. Litts, Angelos Kalitzeos, Christopher S. Langlo, Thomas Kane, Navjit Singh, Melissa Kassilian, Nashila Hirji, Neruban Kumaran, Alfredo Dubra, Joseph Carroll, Michel Michaelides
Abstract
The remnant cone mosaics were irregular and variably disrupted, with significantly lower peak foveal cone density than unaffected individuals. Variability was also seen among subjects with identical mutations. Therefore, subjects should be considered on an individual basis for stratification in clinical trials. Interocular symmetry suggests that both eyes have comparable therapeutic potential and the fellow eye can serve as a valid control. Longitudinal studies are needed, to further examine the weak negative association between age and foveal cone structure observed here.
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