Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow
Investigative Ophthalmology & Visual Science2019Vol. 60(13), pp. 4097–4097
Citations Over TimeTop 21% of 2019 papers
Evan A. Thackaberry, Yi Zhou, Christina L. Zuch de Zafra, Germaine Fuh, Chingwei V. Lee, Sarah Sanowar, John Brady Ridgway, Aija Kusi, Cindy Farman, Helen Booler, Daniel Sheinson, Carol A. Rasmussen, P. Elliott Miller, Eric Wakshull, Minhong Yan, Vladimir Bantseev
Abstract
Dual inhibition of ANGPT1/ANGPT2, but not ANGPT2 alone, leads to increased IOP and glaucomatous damage in monkeys. This confirms a role for TIE2/ANGPT signaling in the control of IOP in adults, a finding initially identified in transgenic mice. Dual pharmacologic inhibition of ANGPT1/ANGPT2 may affect aqueous drainage and homeostasis in adult monkeys and may be useful in developing novel models of glaucoma.
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