Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells
Investigative Ophthalmology & Visual Science2020Vol. 61(1), pp. 1–1
Citations Over TimeTop 10% of 2020 papers
Abstract
These findings demonstrate the possibility that Cdk5/p35 acts as a "cargo" of Vps35 and provide new insights into the pathogenesis of RGC degeneration caused by hyperphosphorylated tau protein. Vps35 is a potential target for basic research and clinical treatment of RGC degeneration in many ocular diseases such as glaucoma.
Related Papers
- → Atypical, non-standard functions of the microtubule associated Tau protein(2017)204 cited
- → Dysregulation of Tau Phosphorylation in Mouse Brain during Excitotoxic Damage(2009)73 cited
- → Visual Disfunction due to the Selective Effect of Glutamate Agonists on Retinal Cells(2021)14 cited
- → Intracortical perfusion of glutamate in vivo induces alterations of tau and microtubule-associated protein 2 immunoreactivity in the rat(1996)31 cited
- → Developing Stage-dependent Retinal Toxicity Induced byl-glutamate in Neonatal Rats(2016)4 cited