Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71
Investigative Ophthalmology & Visual Science2020Vol. 61(2), pp. 11–11
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Mirella Telles Salgueiro Barboni, Cyrille Vaillend, Anneka Joachimsthaler, André Maurício Passos Liber, Hanen Khabou, Michel J. Roux, Ophélie Vacca, Lucile Vignaud, Deniz Dalkara, Xavier Guillonneau, Dora Fix Ventura, Álvaro Rendón, Jan Kremers
Abstract
The present results show successful functional recovery accompanying the reexpression of Dp71. In addition, this experimental model sheds light on MGCs influencing ERG components, since previous reports showed that aquaporin 4 and Kir4.1 channels were mislocated in MGCs of Dp71-null mice, while their distribution could be normalized following intravitreal delivery of the same ShH10-GFP-2A-Dp71 vector.
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