Visual Image Quality Impacts Circadian Rhythm-Related Gene Expression in Retina and in Choroid: A Potential Mechanism for Ametropias
Investigative Ophthalmology & Visual Science2020Vol. 61(5), pp. 13–13
Citations Over TimeTop 16% of 2020 papers
Richard A. Stone, Wenjie Wei, Shanta Sarfare, Brendan McGeehan, K. Cameron Engelhart, Tejvir S. Khurana, Maureen G. Maguire, P. Michael Iuvone, Debora L. Nickla
Abstract
Altering visual input in ways known to induce ametropias alters the retinal/RPE and choroidal expression of circadian rhythm-related genes, further linking circadian biology with eye growth regulation. While further investigations are needed, studying circadian processes may help understand refractive mechanisms and the increasing myopia prevalence in contemporary societies where lighting patterns can desynchronize endogenous rhythms from the natural environmental light/dark cycle.
Related Papers
- → Interactions between the circadian clock and metabolism: there are good times and bad times(2012)24 cited
- → Optical Coherence Tomography of Enucleated Human Eye Specimens With Histological Correlation: Origin of the Outer “Red Line”(2006)19 cited
- Translocation of autologous retinal pigment epithelium and choroid in patients with exudative age–related macular degeneration: further follow–up.(2004)
- Age Alters MicroRNA Expression Profile in Mouse Retinal Pigment Epithelium (RPE)/choroid(2012)
- → Retinal pigment epithelium autotranslocation in traumatic rupture of the choroid in the macular area. Clinical case.(2023)