Crosstalk between EP2 and PPARα Modulates Hypoxic Signaling and Myopia Development in Guinea Pigs
Investigative Ophthalmology & Visual Science2020Vol. 61(8), pp. 44–44
Citations Over TimeTop 15% of 2020 papers
Nethrajeith Srinivasalu, Sen Zhang, Renchang Xu, Peter S. Reinach, Yong‐Chao Su, Yun Zhu, Jia Qu, Xiangtian Zhou
Abstract
EP2 agonism increased cAMP and HIF-1α signaling subsequent to declines in PPARα and RXR mRNA levels, which in turn decreased scleral fibrosis and promoted myopia. EP2 antagonism instead inhibited each of these responses. Our data suggest that EP2 suppression may sustain scleral ECM structure and inhibit myopia development.
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