Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium
Investigative Ophthalmology & Visual Science2021Vol. 62(10), pp. 34–34
Citations Over TimeTop 1% of 2021 papers
Dongfeng Cao, Belinda C. S. Leong, Jeffrey D. Messinger, Deepayan Kar, Thomas Ach, Lawrence A. Yannuzzi, K. Bailey Freund, Christine A. Curcio
Abstract
HRF are indicators not predictors of overall disease activity. Gain and loss of function starts with individual in-layer RPE cells and extends to all abnormal phenotypes. Evidence for RPE transdifferentiation, possibly due to ischemia, supports a proposed process of epithelial-mesenchyme transition. Data can propel new biomarkers and therapeutic strategies for AMD.
Related Papers
- → Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration(2021)59 cited
- → Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography(2008)99 cited
- → Origin of microglia in the quail retina: Central‐to‐peripheral and vitreal‐to‐scleral migration of microglial precursors during development(1995)73 cited
- → Differential permeance of retina and retinal pigment epithelium to water: implications for retinal adhesion(1993)25 cited
- Retinal pigment epithelium (RPE) pigmentary changes are associated with progression from early to advanced age-related macular degeneration (AMD) independent of CFH and ARMS2 risk genotypes.(2020)