Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure
Investigative Ophthalmology & Visual Science2022Vol. 63(4), pp. 22–22
Citations Over TimeTop 22% of 2022 papers
Junji Hamuro, Kazuko Asada, Morio Ueno, Tomoko Yamashita, Atsushi Mukai, Tomoko Fujita, Eiko Ito, Nobuhiro Hiramoto, Munetoyo Toda, Chie Sotozono, Shigeru Kinoshita
Abstract
The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure.
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