Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells
Investigative Ophthalmology & Visual Science2022Vol. 63(6), pp. 8–8
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William W. MacDonald, Swarup S. Swaminathan, Jae Young Heo, Alexandra Castillejos, Jessica Hsueh, Brian J. Liu, Diane Jo, Annie Du, Hyun-Pil Lee, Min Hyung Kang, Douglas J. Rhee
Abstract
Suppressing SPARC decreased IOP in mice and perfused cadaveric human anterior segments corresponding to qualitative structural changes in the JCT ECM, which do not appear to be the result of transcription regulation.
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