SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation
Investigative Ophthalmology & Visual Science2023Vol. 64(3), pp. 16–16
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Lili Lian, Zhenmin Le, Zhenzhen Wang, Ying-ao Chen, Xiaodong Jiao, H. Jerry Qi, J. Fielding Hejtmancik, Xiaoyin Ma, Qinxiang Zheng, Yueping Ren
Abstract
The TXNIP/NLRP3 inflammasome pathway promotes HG-induced inflammation and HLEC pyroptosis, which is negatively regulated by SIRT1. This suggests viable strategies for treating diabetic cataract.
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