NMNAT1 Is Essential for Human iPS Cell Differentiation to the Retinal Lineage
Investigative Ophthalmology & Visual Science2024Vol. 65(12), pp. 37–37
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Hiroshi Kuribayashi, Toshiro Iwagawa, Akira Murakami, Takeshi Kawamura, Yutaka Suzuki, Sumiko Watanabe
Abstract
These results indicate that NMNAT1 was dispensable for neural lineage differentiation but essential for the commitment of retinal fate differentiation in hiPSCs. The NMNAT1-NAD-PARP1 axis may play a critical role in the appropriate development of human retinal lineage differentiation.
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