Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
American Journal of Psychiatry2016Vol. 174(1), pp. 60–69
Citations Over TimeTop 1% of 2016 papers
Premika S.W. Boedhoe, Lianne Schmaal, Yoshinari Abe, Stephanie H. Ameis, Paul Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Kate D. Fitzgerald, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Neda Jahanshad, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Löchner, Rachel Marsh, Ignacio Martínez‐Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Fabrizio Piras, Fabrizio Piras, Christopher Pittenger, Y.C. Janardhan Reddy, João Ricardo Sato, Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido van Wingen, Jian Xu, Xiufeng Xu, Je‐Yeon Yun, Qing Zhao, ENIGMA OCD Working Group, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, The members of the ENIGMA OCD Working Group, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul Arnold, Núria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Premika S.W. Boedhoe, Irene Bollettini, Anushree Bose, Silvia Brem, Geraldo F. Busatto, Anna Calvo, Rosa Calvo, Daniëlle C. Cath, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Froukje E. de Vries, Stella J. de Wit, Damiaan Denys, Yu Fang, Kate D. Fitzgerald, Martine Fontaine, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Neda Jahanshad, Norbert Kathmann, Christian Kaufmann, Sabin Khadka, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Löchner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Eurı́pedes Constantino Miguel, Luciano Minuzzii, Ástrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Fabrizio Piras, Fabrizio Piras, Christopher Pittenger, Y.C. Janardhan Reddy, João Ricardo Sato, Blair Simpson, Lianne Schmaal, Noam Soreni, Carles Soriano‐Mas, Gianfranco Spalletta, Dan J. Stein, Michael C. Stevens, Philip R. Szeszko, Paul M. Thompson, David F. Tolin, Dick J. Veltman, Ganesan Venkatasubramanian, Odile A. van den Heuvel, Ysbrand D. van der Werf, Guido A. van Wingen, Susanne Walitza, Zhen Wang, Jian Xu, Xiufeng Xu, Je-Yeon Yun, Qing Zhao
Abstract
The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.
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