Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
American Journal of Psychiatry2017Vol. 175(5), pp. 453–462
Citations Over TimeTop 1% of 2017 papers
Premika S.W. Boedhoe, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Friðgeirsson, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Neda Jahanshad, Anthony James, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Christine Löchner, Rachel Marsh, Ignacio Martínez‐Zalacaín, David Mataix‐Cols, José M. Menchón, Luciano Minuzzi, Ástrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Seiji Nishida, Erika L. Nurmi, Joseph O’Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y.C. Janardhan Reddy, Tim Jonas Reeß, Yuki Sakai, João Ricardo Sato, H. Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Guido van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Je‐Yeon Yun, ENIGMA-OCD Working Group, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Premika S.W. Boedhoe, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul Arnold, Núria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Daniel Brandeis, Silvia Brem, Elizabeth E.L. Buimer, Geraldo F. Busatto, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Froukje E. de Vries, Stella J. de Wit, Damiaan Denys, Renate Drechsler, Andrea Falini, Yu Fang, Jamie D. Feusner, Martijn Figee, Kate D. Fitzgerald, Martine Fontaine, Jean‐Paul Fouché, Egill A. Fridgeirsson, Patricia Gruner, Gregory L. Hanna, Tobias U. Hauser, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Mariangela Iorio, Neda Jahanshad, Anthony James, Norbert Kathmann, Christian Kaufmann, Sabin Khadka, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Löchner, Rachel Marsh, Ignacio Martínez‐Zalacaín, David Mataix‐Cols, Anthony James, José M. Menchón, Eurı́pedes Constantino Miguel, Luciano Minuzzi, Ástrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Jin Narumoto, Seiji Nishida, Erika Nurmi, Joseph O’Neill, José C. Pariente, John Piacentini, Christopher Pittenger, Fabrizio Piras, Federica Piras, Sara Poletti, Y.C. Janardhan Reddy, Tim Jonas Reeß, Oana Georgiana Rus, Yuki Sakai, João Ricardo Sato, Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, Jinsong Tang, David F. Tolin, Ysbrand D. van der Werf, Guido van Wingen, Daniela Vecchio, Dick J. Veltman, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Anri Watanabe, Jian Xu, Xiufeng Xu, Kei Yamada, Je‐Yeon Yun, Mojtaba Zarei, Qing Zhao, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel
Abstract
The parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.
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