Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
Molecular Cancer2014Vol. 13(1), pp. 28–28
Citations Over TimeTop 10% of 2014 papers
Carme Camps, Harpreet K. Saini, David R. Mole, Hani Choudhry, Martin Reczko, José Afonso Guerra‐Assunção, Ya‐Min Tian, Francesca M. Buffa, Adrian L. Harris, Artemis G. Hatzigeorgiou, Anton J. Enright, Jiannis Ragoussis
Abstract
Integrated analysis of microRNA, mRNA and ChIP-seq data in a model cell line supports the hypothesis that microRNA expression under hypoxia is regulated at transcriptional and post-transcriptional level, with the presence of HIF binding sites at microRNA genomic loci associated with up-regulation. The identification of hypoxia and HIF regulated microRNAs relevant for breast cancer is important for our understanding of disease development and design of therapeutic interventions.
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