The logic of kinetic regulation in the thioredoxin system
BMC Systems Biology2011Vol. 5(1), pp. 15–15
Citations Over TimeTop 17% of 2011 papers
Abstract
Using kinetic modeling we have revealed the logic that underlies the functional organization and kinetic behavior of the thioredoxin system. The thioredoxin redox cycle and associated reactions allows for a system that is adaptable, interconnected and able to display differential sensitivities to changes in this redox cycle. This work provides a theoretical, systems-biological basis for an experimental analysis of the thioredoxin system and its associated reactions.
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