Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues
Arthritis Research & Therapy2008Vol. 10(4), pp. R79–R79
Citations Over TimeTop 20% of 2008 papers
James Melrose, Emily Fuller, Peter J. Roughley, Margaret M. Smith, Briedgeen Kerr, Clare Hughes, Bruce Caterson, Christopher B. Little
Abstract
Enhanced fragmentation of SLRPs is evident in degenerate articular cartilage and meniscus. Specific decorin and fibromodulin core protein fragments in degenerate meniscus and/or human articular cartilage may be of value as biomarkers of disease. Once the enzymes responsible for their generation have been identified, further research may identify them as therapeutic targets.
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