Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination
Arthritis Research & Therapy2008Vol. 10(5), pp. R119–R119
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Brian Kidd, Peggy P. Ho, Orr Sharpe, Xiaoyan Zhao, Beren H. Tomooka, Jennifer L. Kanter, Lawrence Steinman, William H. Robinson
Abstract
Our results suggest that anti-citrulline antibody responses develop in the early stages of CIA and EAE, and that autoimmune inflammation results in citrullination of joint proteins in CIA and brain proteins in EAE, thereby creating neoantigens that become additional targets in epitope spreading of autoimmune responses.
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