Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent
Arthritis Research & Therapy2009Vol. 11(1), pp. R16–R16
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Noreen Pundt, Marvin Peters, Christina Wunrau, Simon Strietholt, Carsten Fehrmann, Katja Neugebauer, Christine Seyfert, F. van Valen, Thomas Pap, Ingmar Meinecke
Abstract
Our data indicate that the susceptibility of RASFs to FasL- and TRAIL-induced apoptosis depends on the cell cycle. These results may explain some conflicting data on the ability of RASFs to undergo FasL- and TRAIL-mediated cell death and suggest that strategies to sensitise RASFs to apoptosis may include the targeting of cell cycle-regulating genes.
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