Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13
Arthritis Research & Therapy2009Vol. 11(2), pp. R41–R41
Citations Over TimeTop 10% of 2009 papers
Christelle Boileau, Johanne Martel‐Pelletier, Judith Caron, Philippe Msika, G.B. Guillou, C. Baudouin, Jean‐Pierre Pelletier
Abstract
This study demonstrates that treatment with avocado/soybean unsaponifiables can reduce the development of early osteoarthritic cartilage and subchondral bone lesions in the anterior cruciate ligament dog model of osteoarthritis. This effect appears to be mediated through the inhibition of inducible nitric oxide synthase and MMP-13, which are key mediators of the structural changes that take place in osteoarthritis.
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