Altered microRNA expression profile with miR-146a upregulation in CD4+T cells from patients with rheumatoid arthritis
Arthritis Research & Therapy2010Vol. 12(3), pp. R81–R81
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Jingyi Li, Ying Wan, Qiuye Guo, Liyun Zou, Jinyu Zhang, Yongfei Fang, Jingbo Zhang, Jinjun Zhang, Xiaolan Fu, Hongli Liu, Liwei Lu, Yuzhang Wu
Abstract
We have detected increased miR-146a in CD4+ T cells of RA patients and its close correlation with TNF-alpha levels. Our findings that miR-146a overexpression suppresses T cell apoptosis indicate a role of miR-146a in RA pathogenesis and provide potential novel therapeutic targets.
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