Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis
Arthritis Research & Therapy2010Vol. 12(3), pp. R86–R86
Citations Over TimeTop 1% of 2010 papers
Koichi Murata, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Kohei Nishitani, Hiromu Ito, Takashi Nakamura
Abstract
Plasma miRNAs had distinct patterns from synovial fluid miRNAs, which appeared to originate from synovial tissue. Plasma miR-132 well differentiated HCs from patients with RA or OA, while synovial fluid miRNAs differentiated RA and OA. Furthermore, plasma miRNAs correlated with the disease activities of RA. Thus, synovial fluid and plasma miRNAs have potential as diagnostic biomarkers for RA and OA and as a tool for the analysis of their pathogenesis.
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