Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
Arthritis Research & Therapy2010Vol. 12(4), pp. R137–R137
Citations Over TimeTop 15% of 2010 papers
Ou Jin, S Kavikondala, Mo-Yin Mok, Lingyun Sun, Jieruo Gu, Rong Fu, Albert W. Chan, Joseph Yeung, Yingjie Nie, Chak Sing Lau
Abstract
We have demonstrated that peripheral circulating pDCs in patients with SLE were functionally abnormal. They lacked TLR9 expression, were less capable of inducing regulatory T cell differentiation and had persistent IL-10 mRNA expression following the capture of apoptotic PMNs. We suggest circulating pDCs may be pathogenically relevant in SLE.
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