Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
Arthritis Research & Therapy2010Vol. 12(4), pp. R152–R152
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Miriam Bellido, Laura Lugo, Jorge A. Roman‐Blas, Santos Castañeda, José Ramón Caeiro, Sonia Dapía, Emílio Calvo, Raquel Largo, Gabriel Herrero‐Beaumont
Abstract
Microstructure impairment at subchondral bone associated with an increased remodelling aggravated cartilage damage in OA rabbits with previous OP. Our results suggest that an increased subchondral bone resorption may account for the exacerbation of cartilage damage when early OA and OP coexist simultaneously in same individuals.
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