Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
Arthritis Research & Therapy2011Vol. 13(2), pp. R69–R69
Citations Over TimeTop 10% of 2011 papers
Terrance P. OʼHanlon, Lisa G. Rider, Lu Gan, Rick D. Fannin, Richard S. Paules, David M. Umbach, Clarice R. Weinberg, Ruchir Shah, Deepak Mav, Mark F. Gourley, Frederick W. Miller
Abstract
Alterations in expression of a limited number of genes may influence the dysregulation of numerous, integrated immune response, cell signaling and regulatory pathways that are common to a number of SAID. Gene expression profiles in peripheral blood suggest that for genes in these critical pathways, unaffected twins may be in a transitional or intermediate state of immune dysregulation between twins with SAID and unrelated controls, perhaps predisposing them to the development of SAID given the necessary and sufficient environmental exposures.
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