Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway
Arthritis Research & Therapy2011Vol. 13(3), pp. R92–R92
Citations Over TimeTop 15% of 2011 papers
Valentina Ulivi, Manuela Lenti, Chiara Gentili, Gabriele Marcolongo, Ranieri Cancedda, Fiorella Descalzi Cancedda
Abstract
All together these data suggest that MGDG has an anti-inflammatory activity in human articular cartilage and possibly activates an anti-inflammatory loop triggered by COX-2 via 15ΔPGJ(2) production, indicating a possible role of COX-2 in resolution of inflammation. The purified compound is a novel anti-inflammatory agent potentially active for human articular cartilage pathologies related to inflammation.
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