Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply
Arthritis Research & Therapy2012Vol. 14(5)
Citations Over Time
Dong Hyun Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C. Erhart‐Hledik, Piyanka Chandra, Lauren J. Lahey, Tamsin M. Lindström, Inyong Hwang, Katherine A. Boyer, Thomas P. Andriacchi, William H. Robinson
Abstract
We thank Oliviero and colleagues for their interest in our recent publication Th eir results strongly support the concept that extravascular plasma proteins may act as damage-associated molecular patterns, and specifi cally as Toll-like receptor 4 agonists. In addition, we note that the NALP-3 infl ammasome exhibits dependence on Toll-like receptor 4 or other mechanisms of priming of IL-1 transcription, thereby generating pro-IL-1 that can be converted to IL-1 by the activated infl ammasome
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