Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
Arthritis Research & Therapy2012Vol. 14(5), pp. R226–R226
Citations Over TimeTop 10% of 2012 papers
Rowan Hardy, Maria Juárez, Amy J. Naylor, Jinwen Tu, Elizabeth Rabbitt, Andrew Filer, Paul M. Stewart, Christopher D. Buckley, Karim Raza, Mark S. Cooper
Abstract
These results demonstrate that in rheumatoid arthritis synovial fibroblasts, DKK1 expression is directly regulated by glucocorticoids rather than TNFα. Consequently, the links between synovial inflammation, altered Wnt signalling and bone remodelling are not direct but are dependent on local activation of endogenous glucocorticoids.
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