A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis
Arthritis Research & Therapy2012Vol. 14(6), pp. R255–R255
Citations Over TimeTop 10% of 2012 papers
Rui Liu, Qian Wu, Dinglei Su, Nan Che, Haifeng Chen, Linyu Geng, Jinyun Chen, Wanjun Chen, Xia Li, Lingyun Sun
Abstract
Increased serum IL-21 levels in RA patients correlate with DAS28, anti-CCP antibody and frequencies of Tfh-like cells. IL-21 supports B cell activation, proliferation and antibody secretion via IL-21R pathway. Thus, IL-21 may be involved in the pathogenesis of RA and antagonizing IL-21 could be a novel strategy for the therapy of RA.
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