High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain
Arthritis Research & Therapy2014Vol. 16(1), pp. R21–R21
Citations Over TimeTop 10% of 2014 papers
Rahul Gawri, Derek H. Rosenzweig, Emerson Krock, Jean Ouellet, Laura S. Stone, Thomas Quinn, Lisbet Haglund
Abstract
HMS culture of IVD cells in vitro drives cytokine and inflammatory responses associated with degenerative disc disease and low-back pain. This study provides evidence for a direct link between cellular strain, secretory factors, neoinnervation and potential degeneration and discogenic pain in vivo.
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