Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis
Arthritis Research & Therapy2014Vol. 16(1), pp. R29–R29
Citations Over TimeTop 10% of 2014 papers
Angela Kill, Christoph Tabeling, Reinmar Undeutsch, Anja A. Kühl, Jeannine Günther, Mislav Radić, Mike Oliver Becker, Harald Heidecke, Margitta Worm, Martin Witzenrath, Gerd‐Rüdiger Burmester, Duska Dragun, Gabriela Riemekasten
Abstract
We conclude that angiotensin and endothelin-receptor activation via anti-AT₁R and anti-ETAR Abs mediate pathogenic effects, indicating their contribution to pathogenesis of SSc. Therefore, anti-AT₁R and anti-ETAR Abs could provide novel targets for therapeutic intervention in the treatment of SSc.
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