Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study
Arthritis Research & Therapy2014Vol. 16(4), pp. R138–R138
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Sarah Tansley, Zoë Betteridge, Harsha Gunawardena, Thomas S. Jacques, Cátherine M. Owens, Clarissa Pilkington, Katie Arnold, Shireena A. Yasin, Elena Moraitis, Lucy R. Wedderburn, Neil McHugh
Abstract
Anti-MDA5 antibodies can be identified in a small but significant proportion of patients with JDM and identify a distinctive clinical sub-group. Screening for anti-MDA5 autoantibodies at diagnosis would be useful to guide further investigation for lung disease, inform on prognosis and potentially confirm the diagnosis, as subtle biopsy changes could otherwise be missed.
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