Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture
Breast Cancer Research2004Vol. 7(1), pp. R46–59
Citations Over TimeTop 13% of 2004 papers
Andrea Sadlonova, Zdeněk Novák, Martin R. Johnson, Damon B. Bowe, Sandra R. Gault, Grier P. Page, Jaideep V. Thottassery, Danny R. Welch, Andra R. Frost
Abstract
Both NAF and CAF have the ability to inhibit the growth of pre-cancerous breast epithelial cells. NAF have greater inhibitory capacity than CAF, suggesting that the ability of fibroblasts to inhibit epithelial cell proliferation is lost during breast carcinogenesis. Furthermore, as the degree of transformation of the epithelial cells increased they became resistant to the growth-inhibitory effects of CAF. Insulin-like growth factor II could not be implicated as a contributor to this differential effect of NAF and CAF on epithelial cell growth.
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