Impact of positive fluid balance on survival in critically ill cancer patients
Citations Over Time
Abstract
Introduction Septic patients frequently develop critical illness myopathies (CIMs) that may represent a crucial factor for prolonged intensive care unit treatment and for ventilator weaning delay. Experimental fi ndings have identifi ed that oxidative stress plays a role in causing muscle depletion in chronic pathological states like sepsis. It is well documented that regular moderate physical exercise can decreased oxidative stress and enhance antioxidant functions. Objective To investigate whether exercise training reduces oxidative damage in septic rats induced by cecal ligation and perforation (CLP). Methods Wistar rats were randomly assigned to three groups: Sham (submitted to a fake surgery), CLP, and CLP that was previously trained (CLPT). The exercise training protocol consisted of 8 weeks of running on a treadmill, 5 days/week, for 60 minutes at 60% of the maximal running speed obtained on the graded treadmill test. Rats were subjected to CLP surgery; after 120 hours of surgical procedure they were killed by decapitation. Oxidative damage of lipids (thiobarbituric acid reactive species (TBARS)) and proteins (carbonyl groups) were analyzed in Soleus (type I fi ber) and plantaris (type II fi ber) muscles. Results See Table
Related Papers
- → Assessment of adrenocortical function in the critically ill(2005)21 cited
- → Electrolyte disorders in the critically ill(2017)3 cited
- The research progress on glycemic management of critically ill patients(2012)
- → Comparison of nutritional screening and diagnostic tools in diagnosis of severe malnutrition in critically ill patients: Preliminary analysis(2018)
- → Glycemic control in critically 111: A review(2017)