Diabetic status and the relation of the three domains of glycemic control tomortality in critically ill patients: an international multicenter cohort study
Critical Care2013Vol. 17(2), pp. R37–R37
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James S. Krinsley, Moritoki Egi, Alex Kiss, Amin N Devendra, Philipp Schüetz, Paula Maurer, Marcus J. Schultz, Roosmarijn TM van Hooijdonk, Morita Kiyoshi, Iain Mackenzie, Djillali Annane, Peter Stow, Stanley A. Nasraway, Sharon Holewinski, Ulrike Holzinger, Jean‐Charles Preiser, Jean‐Louis Vincent, Rinaldo Bellomo
Abstract
Although hyperglycemia, hypoglycemia, and increased glycemic variability is each independently associated with mortality in critically ill patients, diabetic status modulates these relations in clinically important ways. Our findings suggest that patients with diabetes may benefit from higher glucose target ranges than will those without diabetes. Additionally, hypoglycemia is independently associated with increased risk of mortality regardless of the patient's diabetic status, and increased glycemic variability is independently associated with increased risk of mortality among patients without diabetes.
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