Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity
Critical Care2013Vol. 17(5), pp. R226–R226
Citations Over TimeTop 10% of 2013 papers
Abstract
Neutrophils from septic patients exert dramatic compromise of endothelial barrier integrity. This pattern is mimicked by experimental activation of healthy neutrophils. The effect of septic neutrophils on the endothelium depends upon the initial inflammatory event, correlates with organ dysfunction and resolution of sepsis, and is ameliorated by β-glucan.
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