Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study
Critical Care2014Vol. 18(2), pp. R52–R52
Citations Over TimeTop 10% of 2014 papers
Jostein Hagemo, Simon Stanworth, Nicole P. Juffermans, Karim Brohi, Mitchell J. Cohen, Pär I. Johansson, Jo Røislien, Torsten Eken, Paal Aksel Næss, Christine Gaarder
Abstract
Hypofibrinogenaemia is common in trauma and strongly associated with poor outcome. Below an estimated critical fibrinogen concentration value of 2.29 g/L a dramatic increase in mortality was detected. This finding indicates that the negative impact of low fibrinogen concentrations may have been previously underestimated. A number of clinically identifiable factors are associated with hypofibrinogenaemia. They should be considered in the management of massively bleeding patients. Interventional trials with fibrinogen substitution in high-risk patients need to be undertaken.
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